Arsenic Biomethylation and Toxicity Regulation

This study will characterize and compare the kinetic parameters for arsenic biomethylation by N6AMT1 and AS3MT.

Title: Human N6AMT1 and Its Regulation of Arsenic Biomethylation and Toxicity

Principal Investigator: Xuefeng Ren, MD, PhD

Funding Agency: National Institute of Environmental Health Sciences (NIEHS)

Period: 07/24/13 - 06/30/16

Abstract: The primary objective of this study is to characterize and compare the kinetic parameters for arsenic biomethylation by N6AMT1 and AS3MT and investigate their interactive effects on arsenic metabolism and the resulting toxicological responses to arsenic.