Education:
BA, Anthropology Department, University at Buffalo, summa
cum laude, phi beta kappa, 1990
MS, Interdisciplinary Natural Sciences, RPCI, University at
Buffalo, 1992. Thesis: Lung Cancer Histologic Types and
Family History of Cancer: Analysis of Histologic Subtypes
from 872 Primary Lung Cancer Patients.
PhD, Experimental Pathology, RPCI, University at Buffalo,
1994. Thesis: Genetic and Environmental Determinants of
Breast Cancer Risk.
Profile:
Dr. Ambrosone is Chair of the Department of Epidemiology at Roswell Park Cancer Institute and a Professor in the Department of Social and Preventive Medicine at UB. She is a member of NCIs EPIC Study Section and the ACS’s study section on Carcinogenesis, Nutrition and the Environment. She is the 2006 Chair for the Molecular Epidemiology Group of the American Association for Cancer Research, as well as Co-Chair of the Southwest Oncology Group Subcommittee on Molecular Epidemiology. She has more than 70 publications, most related to gene / environment interactions in breast cancer etiology and prognosis.
Research Interests:
Dr. Ambrosone is a molecular epidemiologist with background and expertise in the role of diet, chemical carcinogens, and steroid hormones in cancer risk, particularly that of the breast, prostate and lung, and the role that interindividual variability in metabolism may play in both cancer etiology and prognosis after treatment for cancer. She is PI on a funded case-control study of breast cancer, with a focus on the role of hormonal milieu on the early age at diagnosis and more aggressive disease among African-American women. In a nested case-control study of prostate cancer, she is funded to investigate the role of dietary antioxidants, variability in genes involved in oxidative stress, and cancer risk. Her current interests also include the effects of variability in metabolism of chemotherapeutic agents and response to oxidative stress in relation to survival after treatment for cancer, and she has two active studies to investigate this issue. The role of diet, endogenous antioxidants, and genetic variability in outcomes after cancer diagnosis is an area under current investigation.
Selected Publications:
- Ambrosone CB, McCann SE, Freudenheim JL, Marshall JR, Zheng YZ, Shields PG. Breast Cancer Risk In Premenopausal Women Is Inversely Associated With Consumption Of Broccoli, a Source of Isothiocyanates, But Is Not Significantly Modified By GST Genotypes. J Nutrition 2004;134:1134-1138.
- Rebbeck TR, Ambrosone CB, Bell DA, Chanock S, Hayes R, Kadlubar F, Thomas D. SNP’s, Haplotypes and Cancer: Applications in Molecular Epidemiology. Cancer Epidemiol Biomarkers & Prev 2004;13:681-87.
- Ahn J, Gammon MD, Santella RM, Gaudet MM, Britton JA, Teitelbaum SL, Terry MB, Neugut AI, Josephy PD, Ambrosone CB. Myeloperoxidase (MPO) genotype, fruit and vegetable consumption, and breast cancer risk. Cancer Res 2004;64:7634-7639.
- Joseph MA, Moysich KB, Freudenheim JL, Shields PG, Zhang Y, Marshall JR, Ambrosone CB. Cruciferous Vegetables, Genetic polymorphisms in glutathione S-transferases- M1, -T1 and prostate cancer risk Nutrition and Cancer 2004:50:206-213.
- Ambrosone CB, Ahn J, Singh K, Rezaishiraz H, Furberg H, Sweeney C, Trovato A. Variability in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer Cancer Res 2005;65:1-7.
- Chang-Claude J, Popanda O, Tan XL, Kropp S, Helmbold I, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Schmezer P, AmbrosoneCB. Association between polymorphisms in the DNA repair genes, XRCC1, APE1 and XPD, and acute side effects of radiotherapy in breast cancer patients. Clin Ca Res 2005;11:4802-9.
- Ambrosone CB, Ahn J, Schoenenberger V. Antioxidant Supplements, Genetics, and Chemotherapy Outcomes. Current Cancer Therapy Reviews 2005; I: 251-258.
- Gaudet MM, Gammon DM, Santella RM, Britton JA, Teitelbaum SL, Eng SM, Terry MB, Bensen JT, Schroeder J, Olshan AF, Neugut AI, Ambrosone CB. MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York. Cancer Causes Control 2005;16:1225-34.
- Ahn J, Gammon MD, Santella RM, Gaudet MM, Britton JA, Teitelbaum SL, Terry MB, Nowell S, Davis W, Garza C, Neugut AI, Ambrosone CB. Effect of catalase (CAT) genotype, diet, and supplement use on breast cancer risk. Amer J Epidemiol 2005;162:1-10.
- Popanda O, Tan X-L, Ambrosone CB, Kropp S, Helmbold I, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Schmezer P, Chang-Claude J. Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2 and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients. Cancer Epidemiol Biomarkers & Prev (in press).
- Ahn J, Gammon MD, Santella RM, Gaudet MM, Britton JA, Teitelbaum SL, Terry MB, Neugut AI, Eng SM, Zhang Y, Garza C, Ambrosone CB. Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk. Carcinogenesis (in press).
Professional Affiliations:
Dr. Ambrosone is a member of many professional organizations including the Southwest Oncology Group, the American Association for Cancer Research (AACR), Society for Epidemiologic Research and the American Society for Prevention of Cancer. She also serves as an Senior Editor for Cancer Research, and as a reviewer for a number of journals including the American Journal of Epidemiology, American Journal of Public Health, British Journal of Cancer, Cancer Research, Journal of the American Medical Association, Journal of the National Cancer Institute and The Lancet.
Faculty Links:
Faculty
Page at Roswell Park Cancer Institute |
