Vijaya Prakash Krishnan Muthaiah

PT, PhD, MPH, CPH

Vijaya Prakash Krishnan Muthaiah, PT, PhD.

Vijaya Prakash Krishnan Muthaiah

PT, PhD, MPH, CPH

Vijaya Prakash Krishnan Muthaiah

PT, PhD, MPH, CPH

Research Interests

Auditory/vestibular neurodegeneration in occupational hazards and neurotrauma such as blast induced traumatic brain injury and cerebrovascular accidents.

Overview Publications News Research

Selected Publications

  • Krishnan Muthaiah VP, Cornejo IN, Hariharan S, Thyagarajan M, Gunasekaran K. Disabling tinnitus and third nerve palsy following pontine hemorrhage: Application of ICF framework. Clin Case Rep. 2024; 12:e8405. doi:10.1002/ccr3.8405
  • Butkus, M., Ganesan, M., Muthaiah, V. P. K., & Johnson, M. E. (2023). Utilizing spinal cord injury stratification during classification for allocation of Para surfing sports classes. Journal of Science and Medicine in Sport. https://doi.org/https://doi.org/10.1016/j.jsams.2023.07.003 (IF:4)
  • Martinez VM, Moyano FT, Urrutia CP, Bassaletti CF, Muthaiah VPK, Cornejo IN. Intracochlear schwannoma: about a case. Int J Otorhinolaryngol Head Neck Surg 2023;9:665-7
  • Schmitt, R., Qayum, S., Pliss, A., Kuzmin, A. N., Muthaiah, V. P. K., Kaliyappan, K., ... & Mahajan, S. D. (2023). Mitochondrial Dysfunction and Apoptosis in Brain Microvascular Endothelial Cells Following Blast Traumatic Brain Injury. Cellular and Molecular Neurobiology, 1-13.
  • Krishnan Muthaiah, V. P., Kaliyappan, K., & Mahajan, S. D. Poly ADP Ribose Polymerase-1 inhibition by 3-aminobenzamide recuperates HEI-OC1 auditory hair cells from blast overpressure induced cell death. Frontiers in Cell and Developmental Biology, 11, 120.
  • Liu, Y., Li, F., Shang, S. A., Wang, P., Yin, X., Muthaiah, V. P. K., ... & Chen, Y. C. (2022). Functional-structural large-scale brain networks are correlated with neurocognitive impairment in acute mild traumatic brain injury. QUANTITATIVE IMAGING IN MEDICINE AND SURGERY.
  • Shang S, Ye J, Wu J, Zhang H, Dou W, Krishnan Muthaiah VP, Tian Y, Zhang Y, Chen YC, Yin X. Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson's disease. J Cereb Blood Flow Metab. 2022 Sep;42(9):1719-1731. doi: 10.1177/0271678X221098503. Epub 2022 Apr 26. PMID: 35473430; PMCID: PMC9441726.(IF. 6.2)
  • Bharadwaj HM, Hustedt-Mai AR, Ginsberg HM, Dougherty KM, Muthaiah VPK, Hagedorn A, Simpson JM, Heinz MG. Cross-species experiments reveal widespread cochlear neural damage in normal hearing. Commun Biol. 2022 Jul 22;5(1):733. doi: 10.1038/s42003-022-03691-4. PMID: 35869142; PMCID: PMC9307777.(IF: 6.268).
  • Balakrishnan B, Krishnan Muthaiah VP, Peters-Brinkerhoff C & Ganesan M. Stress, anxiety, and depression in professional graduate students during COVID 19 pandemic, Educational and Developmental Psychologist, 2022 DOI: 10.1080/20590776.2022.2114341
  • Kaliyappan K#, Chen YC, Krishnan Muthaiah VP*. Vestibular Cochlear Manifestations in COVID-19 Cases. Front Neurol. 2022 Mar 18;13:850337. doi: 10.3389/fneur.2022.850337. PMID: 35370886; PMCID: PMC8971520. (IF: 4.003)
  • Zhang Y, Shang S, Hu L, You J, Gu W, Muthaiah VP, Chen YC, Yin X. Cerebral Blood Flow and its Connectivity Deficits in Patients With Lung Cancer After Chemotherapy. Front Mol Biosci. 2022 Mar 23;9:761272. doi: 10.3389/fmolb.2022.761272. PMID: 35402514; PMCID: PMC8983959. (IF: 5.246, Accepted).
  • Li F, Lu L, Shang S, Chen H, Wang P, Muthaiah VP, Yin X, Chen YC. Altered static and dynamic functional network connectivity in post-traumatic headache. J Headache Pain. 2021 Nov 13;22(1):137. doi: 10.1186/s10194-021-01348-x. PMID: 34773973 (IF: 7.277).
  • Rajagopal P, Jayaraman S, Jh SF, Radhakrishnan S, Laxman PA, Krishnan Muthaiah VP, Tripathi SC, Gugapriya TS, Tarnekar AM, Girish Muthiyan G, Deshmukh VR, Sontakke BR, Chandrashekar K. Molecular docking analysis of PARγ with compounds from Ocimum tenuiflorum. Bioinformation. 2021 Nov 30;17(11):928-931. doi: 10.6026/97320630017928. PMID: 35655905; PMCID: PMC9148598.
  • Chandrashekar K, Rajagopal P, Jh SF, Radhakrishnan S, Krishnan Muthaiah VP, Sontakke BR, Deshmukh VR, Periyasamy V, Muthiyan GG, Tarnekar AM, Gugapriya TS, Laxman PA, Tripathi SC, Jayaraman S. Molecular docking analysis of glycogen phosphorylase with inhibitors from Cissampelos pareira Linn. Bioinformation. 2021 Oct 31;17(10):866-869. doi: 10.6026/97320630017866. PMID: 35574507; PMCID: PMC9070628.
  • McNerney K, Kaliyappan K, Wack D, Krishnan Muthaiah VP*. The Influence of Motoric Maneuvers on the Amplitude of Cervical Vestibular Evoked Myogenic Potentials (cVEMP), Journal of American Academy of Audiology (IF: 1.664, In Proof).
  • Kaliyappan K#, Nakuci J, Preda M, Schweser F, Muldoon S, Krishnan Muthaiah VP*. Correlation of histomorphometric changes with diffusion tensor imaging for evaluation of blast-induced auditory neurodegeneration in chinchilla. J Neurotrauma. 2021 Oct 4. doi: 10.1089/neu.2020.7556. Epub ahead of print. PMID: 34605670 (IF: 5.269).
  • Schmitt RR, Kaliyappan K, Muthaiah VPK, Ignatowski TA, Prasad PN, Mahajan SD. Blast-induced injury responsive relative gene expression of traumatic brain injury biomarkers in human brain microvascular endothelial cells. Brain Res. 2021 Nov 1;1770:147642. doi: 10.1016/j.brainres.2021.147642. Epub 2021 Aug 30. PMID: 34474000.(IF:3.252)
  • Zemaitis K, Kaliyappan K, Frerichs V, Friedman A, Krishnan Muthaiah VP*. Mass Spectrometry Imaging of Blast-overpressure Induced modulation of GABA/Glutamate Homeostasis in the Central Auditory Neuraxis of Chinchilla. Experimental and Molecular Pathology, 2020.(IF:3.362)
  • Krishnan Muthaiah, V. P*., Palaniappan, T., Rajan, S. S., Chandrasekar, K., & Venkatachalam, S. (2019). Attenuation of oxidative stress after contusion spinal cord injury through inhibition of Poly ADP Ribose Polymerase involves glutamate cysteine ligase. Process Biochemistry, 84, 180-185. doi:https://doi.org/10.1016/j.procbio.2019.05.030 (IF:3.757)
  • Krishnan Muthaiah VP, Ding D, Salvi R, Roth JA. Carbaryl-induced ototoxicity in rat postnatal cochlear organotypic cultures. Environmental toxicology. 2017; 32(3):956-969. PubMed [journal] PMID: 27296064 (IF:4.119)
  • Krishnan Muthaiah VP, Chen GD, Ding D, Salvi R, Roth JA. Effect of manganese and manganese plus noise on auditory function and cochlear structures. Neurotoxicology. 2016; 55:65-73. PubMed [journal] PMID: 27235191 (IF:4.294)
  • Ding D, Jiang H, Chen GD, Longo-Guess C, Krishnan Muthaiah VP, Tian C, Sheppard A, Salvi R, Johnson KR. N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.  Aging. 2016; 8(4):730-50. PubMed [journal] PMID: 26977590, PMCID: PMC4925825 (IF:5.682)
  • Mullin EJ, Wegst-Uhrich SR, Ding D, Manohar S, Krishnan Muthaiah VP, Salvi R, Aga DS, Roth JA. Effect of manganese treatment on the accumulation on biologically relevant metals in rat cochlea and brain by inductively coupled plasma mass spectrometry. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2015; 28(6):1009-16. PubMed [journal] PMID:  26433897 (IF:2.949)
  • Chen YC, Li X, Liu L, Wang J, Lu CQ, Yang M, Jiao Y, Zang FC, Radziwon K, Chen GD, Sun W, Krishnan Muthaiah VP, Salvi R, Teng GJ. Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network. eLife. 2015; 4:e06576. PubMed [journal] PMID: 25962854, PMCID: PMC4426664 (IF:8.146)
  • Chen YC, Xia W, Luo B, Krisnnan Muthaiah VP, Xiong Z, Zhang J, Wang J, Salvi R, Teng GJ. Frequency-specific alternations in the amplitude of low-frequency fluctuations in chronic tinnitus. Frontiers in neural circuits. 2015; 9:67. PubMed [journal] PMID: 26578894, PMCID: PMC4624866 (IF:3.492)
  • Chen GD, Decker B, Krishnan Muthaiah VP, Sheppard A, Salvi R. Prolonged noise exposure-induced auditory threshold shifts in rats. Hearing research. 2014; 317:1-8. NIHMSID: NIHMS626873 PubMed [journal] PMID: 25219503, PMCID: PMC4252814 (IF:3.208)
  • Muthaiah VPK, Michael FM, Palaniappan T, Rajan SS, Chandrasekar K, Venkatachalam  S. JNK1 and JNK3 play a significant role in both neuronal apoptosis and necrosis. Evaluation based on in vitro approach using tert-butylhydroperoxide induced oxidative stress in neuro-2A cells and perturbation through 3-aminobenzamide. Toxicology in vitro: an international journal published in association with BIBRA. 2017; 41:168-178. PubMed [journal] PMID: 28257805 (IF:3.500)
  • Vijayaprakash KM, Sridharan N. An experimental spinal cord injury rat model using customized impact device: A cost-effective approach. Journal of pharmacology & pharmacotherapeutics. 2013; 4(3):211-3. PubMed [journal] PMID: 23960429, PMCID: PMC3746307 (IF:0.569)
  • Muthaiah VP, Venkitasamy L, Michael FM, Chandrasekar K, Venkatachalam S. Neuroprotective role of naringenin on carbaryl induced neurotoxicity in mouse neuroblastoma cells. Journal of pharmacology & pharmacotherapeutics. 2013; 4(3):192-7. PubMed [journal] PMID: 23960424, PMCID: PMC3746302 (IF:0.569)
  • Muthaiah VP, Nathan AA, Balakrishnan A, Rose R, Gopalsamy J. Impact of occupational health hazards on serum markers of bone formation in spray painters  of Chennai region in Tamil Nadu. Indian journal of occupational and environmental medicine. 2012; 16(2):84-7. PubMed [journal] PMID: 23580840, PMCID: PMC3617514 (IF:1.9)
  • Venkatachalam S, Palaniappan T, Jayapal PK, Neelamegan S, Rajan SS, Muthiah VP. Novel neurotrophic factor secreted by amniotic epithelial cells. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. 2009; 33(2):81-9. PubMed [journal] PMID: 19886035 (IF: 0.983)

Chapter

Human Amniotic Epithelial Cells Transplantation for Contusive Spinal Cord Injury Repair. Prem Kumar Jayapal, Sridharan Neelamegan, Tamilselvi Palaniappan, Sridhar Skylab Rajan, Vijaya Prakash Krishnan Muthaiah, Sankar Venkatachalam (2014), Perinatal Stem Cells, Springer New York: New York, NY, 243-25