Bioactivation of PBDEs by Human Cytochrome P-450

This study aims to characterize the enzyme- and congener-specific metabolism of PBDEs in humans and investigate qualitative and quantitative differences in metabolism which are related to genetic variability in key biotransforming enzymes.

Title: Bioactivation of PBDEs by Human Cytochrome P-450

Principal Investigator: James Olson, PhD

Funding Agency: National Institute of Environmental Health Sciences (NIEHS)

Period: 04/01/12 - 03/31/14

Abstract: The overall objectives of this application are to characterize the enzyme and congener specific metabolism of PBDEs in humans and investigate qualitative and quantitative differences in metabolism which are related to genetic variability in key biotransforming enzymes. The proposed studies will ultimately better inform future mechanistic and epidemiological studies investigating the potential of PBDEs and their metabolites to produce neurobehavioral / neurodevelopmental disorders. In addition, these studies will lead to the identification of potential genetic biomarkers that contribute to interindividual variability in the bioactivation of PBDEs and ultimately the relative susceptibility of individuals to potential adverse effects of these agents.