By examining physiological and psychological measures of stress in police officers, researchers will be able to evaluate potential associations of these measures with early signs of cardiovascular and metabolic disease.
Title: Microvascular Subclinical Cardiovascular Disease (CVD)
Principal Investigator: John Violanti, PhD
Co-investigator: Amy Millen, PhD
Funding Agency: National Institute Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention
Period: 08/01/12 - 07/31/16
Abstract: The study will investigate cross-sectional associations between occupational stressors and promising biomarkers that may reflect adverse micro-vascular changes, as well as the potential role of inflammation, insulin resistance, and serum vitamin D levels in micro-vascular subclinical cardiovascular disease.
Markers of disease include blood pressure; laboratory measurement of lipids, glucose and insulin; and variability of heart rate to assess autonomic nervous-system function. Researchers will conduct ultrasound imaging studies to measure carotid-artery wall thickness, which indicates the risk of atherosclerosis, and reactivity in the brachial artery, the major blood vessel of the upper arm, to determine blood-vessel function.