This is a clinical trial and observational study with primary aims to determine how hormone therapy, diet and calcium/vitamin D affect risk of heart disease, cancer and osteoporosis in postmenopausal women, and to determine the longer term effects of these interventions.
Title: The Womens Health Initiative Regional Field Center Program
Principal Investigator: Jean Wactawski-Wende, PhD
Funding Agency: National Heart, Lung and Blood Institute
Period: 10/01/10 - 10/14/15
Abstract: The Women’s Health Initiative (WHI) is a
large multi-center clinical trial and observational study studying
the major causes of morbidity and mortality in postmenopausal
women. This primary prevention trial and observational study has
assessed the role of hormone therapy, diet and calcium/vitamin D
supplementation on heart disease, cancer and osteoporosis in
postmenopausal women. The WHI is a national study supported by the
National Institutes of Health’s National Heart, Lung and
Blood Institute. Buffalo is one of 40 WHI centers nationally.
The Buffalo center is directed by principal investigators Jean
Wactawski-Wende and Maurizio Trevisan. There are three clinical
The Buffalo WHI Clinical Center was one of the original vanguard
centers for the WHI.
Nationwide, there are more than 162,000 participants enrolled in
the WHI. Locally, there are nearly 4,000 participants from western
The primary endpoints of the three WHI clinical trials have been published. Further results from these studies will continue to be published.