Education:
Ph.D. in Nutrition, Rutgers University, NJ
Post-doctoral training in Biochemistry, University of Iowa
Profile:
Dr. Awad is interested in studying the mechanisms by which
dietary fat influences chronic diseases such as cancer and
cardiovascular diseases.
Research Interests:
Of a special interest, he is investigating the role of plant
sterols (phytosterols) in tumor growth, apoptosis and metastasis.
Phytosterols are found in high concentrations in plant oils
and legumes such as peanuts and peanut products. The mechanisms
under investigation include several signal transduction pathways.
Recently, he has extended his research to examine the protective
role of phytosterols from cardiovascular disease.
Selected Publications:
- Bianca Weinstock-Guttman, Monika Baier, Youngmin Park, Joan Feichter, Peterkin Lee-Kwen, Eileen Gallagher, Jaya Venkatraman, Kulwara Meksawan, Suzanne Deinehert, David Pendergast, Atif B Awad et al (2005) Low fat dietary intervention with ω-3 fatty acid supplementation in multiple sclerosis patients. Prost. Leuko. Essen. Fatty Acids 2005, 73: 397-404.
- Atif B. Awad, Andrew T. Burr and Carol S. Fink (2005) Effect of resveratrol and β-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells • Prost. Leuko. Essen. Fatty Acids 2005, 72: 219-226.
- Atif B. Awad, Carol S. Fink, Elke A. Trautwein and Fady Y. Ntanios (2005) β-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells • J Nutr Biochemistry 16: 650-655
- Awad, A B, Chinnam, M, Fink, C.S. and Bradford, P.G.
Targeting ceramide by dietary means to stimulate apoptosis in tumor cells. Curr. Topics Nutraceutical Res. (2005) 2: 93-100.
- Normen, L., Shaw, C.A., Fink, C.S and Awad, A.B. (2004) Combination of phytosterols and omega-3 fatty acids:
a strategy to promote cardiovascular health. Curr. Med.
Chem.-Cardio. Hemat. Agents 2:1-12.
- Meksawan, K., Pendergast, D.R., Leddy, J.J., Mason,
M. Horvath, P.J. and Awad, A.B. (2004)
Effect of low and high fat diets on nutrient intakes and
selected cardiovascular risk factors in sedentary men
and women. J. Am. Coll. Nutr. 23:131-140.
- Awad, A.B., Toczek, J. and Fink, C.S.
(2004) Phytosterols decrease prostaglandin release in
cultured P388D1/MAB macrophages. Pros. Leuk. Ess. Fatty
Acids 70:511-520.
- Muti, P., Awad, A.B., Schunemann, H.,
Fink, C.S., Hovey, K. et al. (2003) A plant food-based
diet modifies the serum beta-sitosterol concentration
in hyperandrogenic postmenopausal women. J. Nutr. 133:
4252-4255.
- Awad, A.B., Williams, H. and Fink, C.S.
(2003) Effect of phytosterols on cholesterol metabolism
and MAP kinase in MDA-MB-231 human breast cancer cells.
J. Nutr. Biochem. 14:111-119.
- Awad, A.B., Roy, R. and Fink, C.S. (2003)
Beta-sitosterol, a plant sterol, induces apoptosis and
activates key caspases in MDA-MB-231 human breast cancer
cells. Oncol. Res. 10:497-500.
- Li, J.H., Awad, A.B., Fink, C.S., Wu,
Y.W., Hill, L., Trevisan, M. and Muti, P. (2001) Measurement
variability of plasma ß-sitosterol and campesterol,
two new biomarkers for cancer prevention. Europ. J. Cancer
Prev. 10:245-249.
- Awad, A.B., Smith, A.J. and Fink, C.S.
(2001) Plant sterols regulate rat vascular smooth muscle
cell growth and prostacyclin release in culture release
in culture. Post. Leuk. Ess. Fatty Acids 64:323-330.
- Awad, A.B., Fink, C.S. and Ntanois,
F.Y. (2001) Dietary phytosterols lower blood cholesterol
and protect from some types of cancer. Food Ind. J. 4:118-126.
- Awad, A.B., Williams, H. and Fink, C.S.
(2001) Phytosterols reduce in vitro metastic ability of
MDA-MB-231 human breast cancer cells. Nutr. Cancer 40:157-164.
- Awad, A.B., Williams, H., Fink, C.S.
and Kim, U. (2001) In vitro and in vivo (SCID) mice effect
of phytosterols on the growth and dissemination of human
prostate cancer PC-3 cells. Europ J. Cancer Prev. 10:507-513.
- Awad, A.B., Downie, A.C. and Fink, C.S
(2000) Inhibition of growth and stimulation of apoptosis
by ß-sitosterol treatment of MDA-MB-231 human breast
cancer cells in culture. Int. J. Mol. Med. 5:541-545.
- Awad, A.B. and Carol S. Fink (2000)
Phytosterols as Anticancer Dietary Components: Evidence
and Mechanism of Action. J. Nutr. 9:2127-2130.
- Awad, A.B., Downie, A., Fink, C.S. and
Kim, U. (2000) Dietary phytosterols inhibits the growth
and metastasis of MDA-MB-231 human breast cancer cells
grown in SCID mice. Anticancer Res. 20:821-824.
- Awad, A.B., Chan, K.C., Downie, A.C.
and Fink, C.S. (1999) Peanuts as a source of ß-sitosterol,
a sterol with anticancer properties. Nutr. Cancer 36(2):238-241.
Chapter in a Book:
Bradford, P.G and Awad, A.B. (2005)
Phytosterols:Bioactivity on Cancer. In “Nutrition and Cancer Prevention” ( Awad, A.B. and Bradford, P.G., Eds), Taylor and Francis Publisher.
Editor of a book :
Nutrition and Cancer Prevention. (2005)
Awad, A. B. and Bradford, P.G., Editors
Taylor and Francis Publisher
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