This study focuses on the development of a class of new and novel nonparametric likelihood methods for statistical inference.
Principal Investigators: Albert
Vexler, PhD, and Jihnhee
Funding Agency: National Institute of Dental and Craniofacial Research
Abstract: This study focuses on the development of a class of new and novel nonparametric likelihood methods for statistical inference to handle problems encountered during a recent clinical trial, Oral Health and Ventilator- Associated Pneumonia-A Phase III Randomized Single Center Trial.
A total of 175 patients in an intensive care unit were treated with chlorhexidine oral rinse once or twice per day or with a placebo control, and followed until they were discharged. Outcome variables include oral colonization by target micro-organisms, the dental Plaque Index score and diagnostic variables for pneumonia.
Three major issues that warrant the statistical investigation were as follows.
This project proposes the development of statistical inference methods using the nonparametric likelihood approaches to test multiple groups in the presence of incomplete data or data attrition. Some available parametric likelihood approaches can address the missing data problem, however, for incomplete data, these parametric assumptions cannot be tested using standard goodness-of-fit tests. We will develop a series of nonparametric likelihood methods relevant to the structure of incomplete data, where missing patterns are taken into account. These new methods will allow the users to avoid strong distributional assumptions by using a nonparametric approach. We will pay special attention toward utilizing the maximum information retained in the pattern of incomplete data. This novel approach will provide more powerful and accurate analyses. This approach is also immediately useful for the analysis of oral health data in general, since common dental caries or periodontal disease datasets are riddled with similar missing data problems.