Education
B.A. English. Arizona State University, Tempe, Arizona, 1995
B.S. Economics Arizona State University, Tempe, Arizona, 2001
M.S., Operations Research, Department of Industrial Engineering, School of Engineering, State University of New York at Buffalo, Buffalo, New York, 2003
Ph.D. Division of Genetic and Molecular Epidemiology, Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 2007
Dissertation Title: Statistical Methods for the Genetic Analysis of Developmental Disorders
Research Interests
My research interests encompass both the molecular and genetic causes for complex diseases and the methodology used to find these mechanisms. In the past 10 years, over 100 disease-causing genes were identified; however these were mostly for single gene disorders. The most difficult challenge still lies ahead of us in finding genes involved in diseases with complex patterns of inheritance, such as those that contribute to cancer. In most of these cases, no single gene is likely to be absolutely responsible for whether a person has a disease. It is more likely that changes in more than one gene will be required before the disease is manifest. This complexity requires new approaches to the analysis of genetic data; as a genetic epidemiologist my research has two focuses, methods development and cancer. I would like to continue to adapt and explore mathematical approaches from fields outside of biology for finding genetic interactions and complex genetic phenomenon, such as effect modifier and pleiotropic genes as well as the role of admixture (and self-identified race) in etiology and severity of disease. My areas of interest in cancer epidemiology are ovarian and endometrial cancer as well as hematologic malignancies. In specific, the role of immunity and inflammation in disease process and the use of immune markers as endophenotypes for better disease detection and classification.
Publications
- Bernstein JM, Anon J, Rontal M, Wang K, Conroy J, Sucheston L. Genetic Polymorphisms in Chronic Hyperplastic Sinusitis with Nasal Polyposis, Laryngoscope. In press
- Chanda P, Zhang A, Sucheston L, Ramanathan M. An Information Theoretic Search Strategy for Detecting Multiple Loci Associated with Rheumatoid Arthritis BMC Proceedings. In press
- Chanda P, Sucheston L, Zhang A, Tritchler D, Ramanathan M. Prioritizing Genetic Variations and Environmental Factors associated with disease for further analysis. European Journal of Human Genetics. In press
- Chanda P, Sucheston L, Liu S, Zhang A, Ramanathan M. Information-Theoretic Gene-Gene and Gene-Environment Interaction Analysis of Quantitative Traits. BMC Genomics. In press
- Chanda P, Sucheston L, Zhang A, Brazeau D, Freudenheim JL, Ambrosone C, Ramanathan M. (2008) AMBIENCE: A Novel Approach and Efficient Algorithm for Identifying Informative Genetic and Environment Interactions Associated with Complex Phenotypes. Genetics 108(2)
- Chanda P, Zhang A, Brazeau D, Sucheston L, Freudenheim J, Ambrosone C, Ramanathan M. (2007) Information Theoretic Metrics for Visualizing Gene Environment Interactions American Journal of Human Genetics. 81 (Nov): 939–963
- Lewis B, Freebairn L, Hansen A, Miscimarra LE, Iyengar S, Taylor H. (2007) Speech and Language Skills of Parents of Children with Speech Sound Disorders, American Journal of Speech and Language Pathology, 16(May):108-118
- Cartier KC, Miscimarra LE, Hazard J, Song Y, Iyengar SK and Rao JS. (2007) Studying Genetic Determinants of Natural Variation in Human Gene Expression Using Bayesian ANOVA, BMC Proceedings, 1(Suppl 1): S115
- Miscimarra LE, Stein C, Millard C, Kluge A, Cartier K, Freebairn L, Hansen A, Shriberg L, Taylor H, Iyengar SK. (2007) Further Evidence of Pleiotropy Influencing Speech and Language: Analysis of the DYX8 region, Human Heredity, 63(1):47-58
- Stein C, Millard C, Kluge A, Miscimarra LE, Cartier K, Freebairn L, Hansen A, Shriberg L, Taylor H, Lewis B, Iyengar S. (2006) Speech sound disorder influenced by locus in 15q14 region, Journal of Behavior Genetics, 36(6):858-68
Professional Organizations
American Association of Cancer Researchers
American Society of Human Genetics
American Statistical Association, President Buffalo Chapter
International Genetic Epidemiology Society
Society for Epidemiologic Research
Faculty Links
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